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Cysticercosis
by the Year 2000: an Update
Sirivan Vanijanonta
Department of Clinical Tropical Medicine, Faculty of Tropical Medicine,
Mahidol University, Bangkok, Thailand
Abstract
Cysticercosis is a common parasitic infection of populations in the tropical countries. It is
due to infection by the larval stage of Taenia solium. Man acquires the infection by accidentally
ingesting T. solium eggs. The incidence of this disease seems to be increasing in both endemic
areas and non-endemic areas. The real incubation period is uncertain. Cysticerci can lodge
anywhere in the human body but subcutaneous tissues, muscles, eyes and nervous system are
more commonly affected. The larval parasites seem to have a special predilection for the central
nervous system, where they can invade the parenchyma, the subarachnoidal spaces and the
ventricular system. Clinical manifestations vary from asymptomatic to severe clinical disorders,
especially in those with cerebral involvement. Neurocysticercosis presents various clinical signs
and symptoms according to the site, number and size of cysts, and the stage of infection. Previously
cysticercosis, either extracerebral or cerebral, was treated symptomatically. Steroids have been
used for those with evidence of severe inflammatory reactions. Since the 1980s, the introduction
of praziquantel and albendazole made the treatment of cysticercosis more effective. Multi-center
studies claimed that albendazole was superior to praziquantel, especially for the treatment of
ventricular cysts. CT and MRI made the diagnosis and radiological classification of the cysts,
including the site and stage, and the interpretation of the drug’s response more impressive. The
conventional treatment by albendazole and praziquantel has recently been reduced to an 8-day
regimen. Praziquantel also gives satisfactory results as an ultra-short course one-day treatment.
Surgical procedures are still needed for patients with intraventricular cysts and increased
intracranial pressure. Other essential drugs are anticonvulsants, analgesics and antipsychologics.
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